Ontology highlight
ABSTRACT:
SUBMITTER: Damkier P
PROVIDER: S-EPMC5552748 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Damkier Per P Kjærsgaard Anders A Barker Kimberly A KA Cronin-Fenton Deidre D Crawford Anatasha A Hellberg Ylva Y Janssen Emilius A M EAM Langefeld Carl C Ahern Thomas P TP Lash Timothy L TL
Scientific reports 20170810 1
The role of cytochrome P450 drug metabolizing enzymes in the efficacy of tamoxifen treatment of breast cancer is subject to substantial interest and controversy. CYP2D6 have been intensively studied, but the role of CYP2C19 is less elucidated, and we studied the association of CYPC19 genotype and recurrence of breast cancer. We used outcome and genotyping data from the large publicly available International Tamoxifen Pharmacogenomics Consortium (ITPC) dataset. Cox regression was used to compute ...[more]