Clinical metagenomics of bone and joint infections: a proof of concept study.
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ABSTRACT:
SUBMITTER: Ruppe E
PROVIDER: S-EPMC5552814 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Publications
Clinical metagenomics of bone and joint infections: a proof of concept study.
Ruppé Etienne E Lazarevic Vladimir V Girard Myriam M Mouton William W Ferry Tristan T Laurent Frédéric F Schrenzel Jacques J
Scientific reports 20170810 1
Bone and joint infections (BJI) are severe infections that require a tailored and protracted antibiotic treatment. Yet, the diagnostic based on culturing samples lacks sensitivity, especially for hardly culturable bacteria. Metagenomic sequencing could potentially address those limitations. Here, we assessed the performances of metagenomic sequencing on 24 BJI samples for the identification of pathogens and the prediction of their antibiotic susceptibility. For monomicrobial samples in culture ( ...[more]
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