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Childhood and teenage physical activity and breast cancer risk.

ABSTRACT: PURPOSE:Adult physical activity is associated with reduced breast cancer risk, but few studies have evaluated activity before adulthood. Early life may be an important period because of rapid breast development and hormonal changes. This study contributes new information by examining childhood (ages 5-12) and teenage (ages 13-19) activity separately and overall. METHODS:The Sister Study is a cohort of 50,884 women aged 35-74. Women reported age 5-19 sports/exercise activities and age 10 and 16 unstructured activities. Both hours and MET-hours of activity were considered in association with breast cancer overall, by ER status, and by menopausal status. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with Cox proportional hazards models. RESULTS:2416 cases were diagnosed during follow-up (mean = 6.4 years). Participation in 7+ hours (vs <1 h) per week of sports/exercise during ages 5-19 was associated with reduced breast cancer risk (HR = 0.75; 95% CI 0.57-0.99). 7+ hours (vs <1 h) per week of unstructured physical activity at age 16, but not age 10, was inversely associated with breast cancer (HR = 0.81; 95% CI 0.70-0.95). Associations were more pronounced for ER+ tumors, especially for activity during the childhood (ages 5-12) period. Due to low correlation between childhood/teenage and adulthood activity in this study (r = 0.1), it is unlikely that recent activity explains our results. CONCLUSIONS:Findings from this large cohort indicate higher levels of physical activity during ages 5-19 are inversely associated with breast cancer risk, supporting early life as a window of susceptibility for breast cancer development.

SUBMITTER: Niehoff NM

PROVIDER: S-EPMC5553118 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Childhood and teenage physical activity and breast cancer risk.

Niehoff Nicole M NM White Alexandra J AJ Sandler Dale P DP

Breast cancer research and treatment 20170512 3

<h4>Purpose</h4>Adult physical activity is associated with reduced breast cancer risk, but few studies have evaluated activity before adulthood. Early life may be an important period because of rapid breast development and hormonal changes. This study contributes new information by examining childhood (ages 5-12) and teenage (ages 13-19) activity separately and overall.<h4>Methods</h4>The Sister Study is a cohort of 50,884 women aged 35-74. Women reported age 5-19 sports/exercise activities and ...[more]

PMID: 28500399

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Project description:BackgroundIt is recommended that young people should engage in 60 min of moderate-to-vigorous activity (MVPA) a day for health benefits, but few teenagers actually meet this recommendation. Policy-makers play a vital role in designing physical activity initiatives, but they generally do this with little or no input from the intervention recipients. This study explores the recommendations made by teenagers to improve activity provision, uptake and sustainability of physical activity engagement for both themselves and their peers.MethodsThirteen focus groups were carried out in seven secondary schools in South Wales, United Kingdom. Participants (n = 78) were recruited from a larger mixed-method randomised control trial, which involved the implementation of a voucher scheme to promote physical activity in teenagers (aged 13-14). Thematic analysis was undertaken to identify key issues from the perspective of the teenage participants.ResultsSix key recommendations were identified following analysis of the focus groups: i) Lower/remove the cost of activities without sacrificing the quality, ii) Make physical activity opportunities more locally accessible, iii) Improve the standards of existing facilities, iv) Make activities more specific to teenagers v) Give teenagers a choice of activities/increase variety of activity and vi) Provide activities that teenage girls enjoy (e.g., fun, sociable and not competitive sport). Throughout the focus groups, the increased opportunity to participate in unstructured activity was a key recommendation echoed by both boys and girls in all themes.ConclusionThere is a disconnect between what is available and what teenagers want to do. Policy-makers and those involved in physical activity delivery (e.g., schools, local council and local activity providers) should include young people in designing interventions and facilities to ensure they are meeting the needs of this age group and providing the right opportunities for teenagers to be active. That is unstructured, local, low cost, fun, sociable opportunities and the right facilities to be active.

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Childhood and teenage physical activity and breast cancer risk.

Publications

Childhood and teenage physical activity and breast cancer risk.

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