Recurrent SERPINB3 and SERPINB4 mutations in patients who respond to anti-CTLA4 immunotherapy.
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ABSTRACT:
SUBMITTER: Riaz N
PROVIDER: S-EPMC5553281 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
Recurrent SERPINB3 and SERPINB4 mutations in patients who respond to anti-CTLA4 immunotherapy.
Riaz Nadeem N Havel Jonathan J JJ Kendall Sviatoslav M SM Makarov Vladimir V Walsh Logan A LA Desrichard Alexis A Weinhold Nils N Chan Timothy A TA
Nature genetics 20160926 11
Immune checkpoint blockade has shown significant promise as an anticancer treatment, yet the determinants of response are not completely understood. Here we show that somatic mutations in SERPINB3 and SERPINB4 are associated with survival after anti-CTLA4 immunotherapy in two independent cohorts of patients with melanoma (n = 174). Interestingly, serpins are homologs of the well-known ovalbumin antigen and are associated with autoimmunity. Our findings have implications for the personalization o ...[more]
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