Role of a p53 polymorphism in the development of nonfunctional pituitary adenomas.
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ABSTRACT:
SUBMITTER: Yagnik G
PROVIDER: S-EPMC5553295 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
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Role of a p53 polymorphism in the development of nonfunctional pituitary adenomas.
Yagnik Garima G Jahangiri Arman A Chen Rebecca R Wagner Jeffrey R JR Aghi Manish K MK
Molecular and cellular endocrinology 20170216
Non-functional pituitary adenomas (NFPAs) are among the commonest intracranial neoplasms. While histologically benign, NFPAs sometimes become large enough to limit therapeutic options and reduce quality of life. Investigations of the molecular etiology of NFPAs have failed to identify prevalent genetic changes and, while a role for p53 has been suggested, TP53 gene alterations have yet to be described in NFPAs. We found that the polymorphism rs1042522:C > G in codon 72 of exon 4 of the TP53 gene ...[more]
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