Ontology highlight
ABSTRACT:
SUBMITTER: Gentilella A
PROVIDER: S-EPMC5553558 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Gentilella Antonio A Morón-Duran Francisco D FD Fuentes Pedro P Zweig-Rocha Guilherme G Riaño-Canalias Ferran F Pelletier Joffrey J Ruiz Marta M Turón Gemma G Castaño Julio J Tauler Albert A Bueno Clara C Menéndez Pablo P Kozma Sara C SC Thomas George G
Molecular cell 20170629 1
Ribosomal protein (RP) expression in higher eukaryotes is regulated translationally through the 5′TOP sequence. This mechanism evolved to more rapidly produce RPs on demand in different tissues. Here we show that 40S ribosomes, in a complex with the mRNA binding protein LARP1, selectively stabilize 5′TOP mRNAs, with disruption of this complex leading to induction of the impaired ribosome biogenesis checkpoint (IRBC) and p53 stabilization. The importance of this mechanism is underscored in 5q− sy ...[more]