Genetic variants specific to aging-related verbal memory: Insights from GWASs in a population-based cohort.

ABSTRACT: Verbal memory is typically studied using immediate recall (IR) and delayed recall (DR) scores, although DR is dependent on IR capability. Separating these components may be useful for deciphering the genetic variation in age-related memory abilities. This study was conducted to (a) construct individual trajectories in IR and independent aspects of delayed recall, or residualized-DR (rDR), across older adulthood; and (b) identify genetic markers that contribute to four estimated phenotypes: IR and rDR levels and changes after age 60. A cognitively intact sample (N = 20,650 with 125,164 observations) was drawn from the U.S. Health and Retirement Study, a nationally representative study of adults aged 50 and older. Mixed effects regression models were constructed using repeated measures from

SUBMITTER: Arpawong TE 

PROVIDER: S-EPMC5553750 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature