Ontology highlight
ABSTRACT:
SUBMITTER: Miller AK
PROVIDER: S-EPMC5554117 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Miller Anna K AK Munger Karl K Adler Frederick R FR
Bulletin of mathematical biology 20170612 7
Human papillomaviruses (HPVs) that infect mucosal epithelium can be classified as high risk or low risk based on their propensity to cause lesions that can undergo malignant progression. HPVs produce the E7 protein that binds to cell cycle regulatory proteins including the retinoblastoma tumor suppressor protein (RB) to modulate cell cycle control. Generally, high-risk HPV E7 proteins bind to RB with a higher affinity than low-risk HPV E7s, but both are able to deactivate RB and trigger S phase ...[more]