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Colossal piezomagnetic response in magnetically pressed Zr⁺⁴ substituted cobalt ferrites.

ABSTRACT: A remarkable 111% increase in magnetostriction (?) and 435% increase in strain sensitivity (d?/dH) (compared to normally compacted (NC) unsubstituted CoFe₂O₄ (CFO)) of Zr⁺⁴ doped CFO sample, Co_1.2Zr_0.2Fe_1.6O₄, prepared by magnetic field assisted compaction, have been reported in this study. Magnetic field assisted compaction (MC) has been employed to process Zr-doped cobalt ferrites, Co_1+xZr_xFe_2-2xO₄ (0???×???0.4), to further improve the magnetoelastic properties. Saturation magnetization (M _S ) and coercivity (H _C ) increase from ~426?kA/m and ~4.4?kA/m respectively, for x?=?0, to ~552?kA/m and ~7.11?kA/m respectively for x?=?0.2. Dramatic increase in ? was observed for MC samples (~ -360?ppm and ~-380?ppm for x?=?0 and x?=?0.2 respectively) compared to the NC samples (~-181?ppm and ~-185?ppm for x?=?0 and x?=?0.2 respectively). A remarkable quadruple increase in d?/dH was observed in Zr-doped (x?=?0.2) cobalt-ferrite (~4.3?×?10^-9 A^-1m) compared to that of unsubstituted cobalt-ferrite (~1.24?×?10^-9 A^-1m), while a fivefold increase in d?/dH was observed for magnetically compacted (MC) Zr doped cobalt ferrite (x?=?0.2) (~4.3?×?10^-9 A^-1m) compared to normal compacted (NC) unsubstituted cobalt ferrite (~0.8?×?10^-9 A^-1m).

SUBMITTER: Reddy MV

PROVIDER: S-EPMC5554159 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Colossal piezomagnetic response in magnetically pressed Zr+4 substituted cobalt ferrites.

Reddy Monaji Vinitha MV Lisfi Abdellah A Pokharel Sabin S Das Dibakar D

Scientific reports 20170811 1

A remarkable 111% increase in magnetostriction (λ) and 435% increase in strain sensitivity (dλ/dH) (compared to normally compacted (NC) unsubstituted CoFe2O4 (CFO)) of Zr+4 doped CFO sample, Co1.2Zr0.2Fe1.6O4, prepared by magnetic field assisted compaction, have been reported in this study. Magnetic field assisted compaction (MC) has been employed to process Zr-doped cobalt ferrites, Co1+xZrxFe<sub ...[more]

PMID: 28801628

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Project description:BackgroundIn vivo monitoring of cell biodistribution using positron emission tomography (PET) provides a quantitative non-invasive method to further optimize cell therapies and related new developments in the field. Our group has earlier optimized and evaluated the in vitro properties of two radiotracers,[89Zr]Zr-(oxinate)4 and [89Zr]Zr-DFO-NCS, for the radiolabelling of different cell types. Here, we performed a microPET study to assess the in vivo biodistribution of cells in rats using these two radiotracers. Human decidual stromal cells (hDSC) and rat macrophages (rMac) were radiolabelled with [89Zr]Zr-(oxinate)4 or [89Zr]Zr-DFO-NCS. Rats were intravenously injected with radiolabelled cells, and the in vivo biodistribution was monitored with microPET/CT imaging for up to day 7. Organ uptake was evaluated and presented as a percentage of injected activity per gram tissue (%IA/g) and total absorbed organ doses (mSv/MBq).ResultsThe biodistribution in vivo showed an immediate uptake in the lungs. Thereafter, [89Zr]Zr-(oxinate)4 labelled cells migrated to the liver, while the signal from [89Zr]Zr-DFO-NCS labelled cells lingered in the lungs. The differences in the in vivo behaviour for the same cell type appeared related to the radiotracer labelling. After 24 h, [89Zr]Zr-(oxinate)4 labelled cells had over 70% higher liver uptake for both hDSC and rMac compared to [89Zr]Zr-DFO-NCS labelled cells, whereas [89Zr]Zr-DFO-NCS labelled cells showed over 60% higher uptake in the lungs compared to [89Zr]Zr-(oxinate)4 labelled cells. This difference in both lung and liver uptake continued until day 7. Dosimetry calculations showed a higher effective dose (mSv/MBq) for [89Zr]Zr-DFO-NCS compared to [89Zr]Zr-(oxinate)4, for both cell types. Although the bone uptake was higher for [89Zr]Zr-(oxinate)4 labelled cells, the prolonged uptake in the lungs contributed to a significant crossfire to bone marrow resulting in a higher bone dose.ConclusionThe [89Zr]Zr-DFO-NCS labelled cells suggest a prolonged accumulation in the lungs, while [89Zr]Zr-(oxinate)4 suggests quicker clearance of the lungs followed by accumulation in the liver. Accumulation of radiolabelled cells in the liver corresponds to other cell-tracking methods. Further studies are required to determine the actual location of the [89Zr]Zr-DFO-NCS labelled cell.

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Colossal piezomagnetic response in magnetically pressed Zr⁺⁴ substituted cobalt ferrites.

Publications

Colossal piezomagnetic response in magnetically pressed Zr<sup>+4</sup> substituted cobalt ferrites.

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