Ontology highlight
ABSTRACT:
SUBMITTER: Chaudhury S
PROVIDER: S-EPMC5554171 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Chaudhury Sidhartha S Regules Jason A JA Darko Christian A CA Dutta Sheetij S Wallqvist Anders A Waters Norman C NC Jongert Erik E Lemiale Franck F Bergmann-Leitner Elke S ES
Scientific reports 20170811 1
A recent study of the RTS,S malaria vaccine, which is based on the circumsporozoite protein (CSP), demonstrated an increase in efficacy from 50-60% to 80% when using a delayed fractional dose regimen, in which the standard 0-1-2 month immunization schedule was modified to a 0-1-7 month schedule and the third immunization was delivered at 20% of the full dose. Given the role that antibodies can play in RTS,S-induced protection, we sought to determine how the modified regimen alters IgG subclasses ...[more]