Ontology highlight
ABSTRACT:
SUBMITTER: Tomoishi S
PROVIDER: S-EPMC5554210 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Scientific reports 20170811 1
Hepatic fibrosis is caused by exaggerated wound healing response to chronic injury, which eventually leads to hepatic cirrhosis. Differentiation of hepatic stellate cells (HSCs) to myofibroblast-like cells by inflammatory cytokines is the critical step in fibrosis. This step is accompanied by enlargement of the endoplasmic reticulum (ER) and Golgi apparatus, suggesting that protein synthesis and secretion are augmented in the activated HSCs. However, the process of rearrangement of secretory org ...[more]