Ontology highlight
ABSTRACT:
SUBMITTER: Tanasescu R
PROVIDER: S-EPMC5554296 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Tanasescu Radu R Cottam William J WJ Condon Laura L Tench Christopher R CR Auer Dorothee P DP
Neuroscience and biobehavioral reviews 20160507
Maladaptive mechanisms of pain processing in chronic pain conditions (CP) are poorly understood. We used coordinate based meta-analysis of 266 fMRI pain studies to study functional brain reorganisation in CP and experimental models of hyperalgesia. The pattern of nociceptive brain activation was similar in CP, hyperalgesia and normalgesia in controls. However, elevated likelihood of activation was detected in the left putamen, left frontal gyrus and right insula in CP comparing stimuli of the mo ...[more]