Maternal serum PFOA concentration and DNA methylation in cord blood: A pilot study.
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ABSTRACT:
SUBMITTER: Kingsley SL
PROVIDER: S-EPMC5554452 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
Maternal serum PFOA concentration and DNA methylation in cord blood: A pilot study.
Kingsley Samantha L SL Kelsey Karl T KT Butler Rondi R Chen Aimin A Eliot Melissa N MN Romano Megan E ME Houseman Andres A Koestler Devin C DC Lanphear Bruce P BP Yolton Kimberly K Braun Joseph M JM
Environmental research 20170620
Perfluorooctanoic acid (PFOA), a perfluoroalkyl substance, is commonly detected in the serum of pregnant women and may impact fetal development via epigenetic re-programming. In a pilot study, we explored associations between serum PFOA concentrations during pregnancy and offspring peripheral leukocyte DNA methylation at delivery in women with high (n = 22, range: 12-26ng/mL) and low (n = 22, range: 1.1-3.1ng/mL) PFOA concentrations. After adjusting for cell type, child sex, and income, we did n ...[more]
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