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ABSTRACT: Objectives
The olfactory nerve is anatomically susceptible to injury from pollution in inspired air, but there are no large-scale epidemiologic studies investigating this relationship.Methods
Cross-sectional study using data from the National Social Life, Health, and Aging Project, a representative sample of home-dwelling US adults age 57-85 years. Olfactory function was tested using a validated 5-item odor identification test (Sniffin' Sticks). Exposure to fine particulate matter (PM2.5) at each respondent's home was estimated as 1-12 month moving averages prior to olfactory assessment using validated spatio-temporal models.Results
Olfactory dysfunction was significantly associated with PM2.5 exposures averaged over 3-12 months in urban-dwelling respondents. The strongest effect was for 6 month average exposure (per 1-IQR increase in PM2.5: OR 1.28, 95% CI 1.05, 1.55) adjusting for age, gender, race/ethnicity, education, cognition, comorbidity, smoking, and the season. Interestingly, the most deleterious effects were observed among the youngest respondents, 57-64 years old, and those living in the northeast and south.Conclusions
We show for the first time that air pollution exposure is associated with poor olfaction among urban-living, older US adults.
SUBMITTER: Ajmani GS
PROVIDER: S-EPMC5554594 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Ajmani Gaurav S GS Suh Helen H HH Wroblewski Kristen E KE Kern David W DW Schumm L Philip LP McClintock Martha K MK Yanosky Jeff D JD Pinto Jayant M JM
Environmental research 20160929
<h4>Objectives</h4>The olfactory nerve is anatomically susceptible to injury from pollution in inspired air, but there are no large-scale epidemiologic studies investigating this relationship.<h4>Methods</h4>Cross-sectional study using data from the National Social Life, Health, and Aging Project, a representative sample of home-dwelling US adults age 57-85 years. Olfactory function was tested using a validated 5-item odor identification test (Sniffin' Sticks). Exposure to fine particulate matte ...[more]