Ontology highlight
ABSTRACT:
SUBMITTER: Winter-Vann AM
PROVIDER: S-EPMC555472 | biostudies-literature | 2005 Mar
REPOSITORIES: biostudies-literature
Winter-Vann Ann M AM Baron Rudi A RA Wong Waihay W dela Cruz June J York John D JD Gooden David M DM Bergo Martin O MO Young Stephen G SG Toone Eric J EJ Casey Patrick J PJ
Proceedings of the National Academy of Sciences of the United States of America 20050301 12
Many key regulatory proteins, including members of the Ras family of GTPases, are modified at their C terminus by a process termed prenylation. This processing is initiated by the addition of an isoprenoid lipid, and the proteins are further modified by a proteolytic event and methylation of the C-terminal prenylcysteine. Although the biological consequences of prenylation have been characterized extensively, the contributions of prenylcysteine methylation to the functions of the modified protei ...[more]