Ontology highlight
ABSTRACT:
SUBMITTER: Mohammed H
PROVIDER: S-EPMC5554778 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Mohammed Hisham H Hernando-Herraez Irene I Savino Aurora A Scialdone Antonio A Macaulay Iain I Mulas Carla C Chandra Tamir T Voet Thierry T Dean Wendy W Nichols Jennifer J Marioni John C JC Reik Wolf W
Cell reports 20170801 5
The mouse inner cell mass (ICM) segregates into the epiblast and primitive endoderm (PrE) lineages coincident with implantation of the embryo. The epiblast subsequently undergoes considerable expansion of cell numbers prior to gastrulation. To investigate underlying regulatory principles, we performed systematic single-cell RNA sequencing (seq) of conceptuses from E3.5 to E6.5. The epiblast shows reactivation and subsequent inactivation of the X chromosome, with Zfp57 expression associated with ...[more]