Ontology highlight
ABSTRACT:
SUBMITTER: Yang HJ
PROVIDER: S-EPMC5555082 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Yang Hong-Ju HJ Zhang Hai-Ying HY Bi Guo-Hua GH He Yi Y Gao Jun-Tao JT Xi Zheng-Xiong ZX
Cell reports 20170701 2
Cocaine users show reduced expression of the metabotropic glutamate receptor (mGluR2), but it is not clear whether this is a predisposing trait for addiction or a consequence of drug exposure. In this study, we found that a nonsense mutation at the mGluR2 gene decreased mGluR2 expression and altered the seeking and taking of cocaine. mGluR2 mutant rats show reduced sensitivity to cocaine reward, requiring more cocaine to reach satiation when it was freely available and ceasing their drug-seeking ...[more]