Ontology highlight
ABSTRACT:
SUBMITTER: Xue Y
PROVIDER: S-EPMC5555183 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Xue Yong Y Schmollinger Stefan S Attar Narsis N Campos Oscar A OA Vogelauer Maria M Carey Michael F MF Merchant Sabeeha S SS Kurdistani Siavash K SK
The Journal of biological chemistry 20170621 32
The endoplasmic reticulum (ER)-mitochondria encounter structure (ERMES) is a protein complex that physically tethers the two organelles to each other and creates the physical basis for communication between them. ERMES functions in lipid exchange between the ER and mitochondria, protein import into mitochondria, and maintenance of mitochondrial morphology and genome. Here, we report that ERMES is also required for iron homeostasis. Loss of ERMES components activates an Aft1-dependent iron defici ...[more]