Ontology highlight
ABSTRACT:
SUBMITTER: Shimizu H
PROVIDER: S-EPMC5555202 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Shimizu Hikaru H Toma-Fukai Sachiko S Saijo Shinya S Shimizu Nobutaka N Kontani Kenji K Katada Toshiaki T Shimizu Toshiyuki T
The Journal of biological chemistry 20170619 32
Small GTPases are molecular switches that have critical biological roles and are controlled by GTPase-activating proteins and guanine nucleotide exchange factors (GEFs). The smg GDP dissociation stimulator (SmgGDS) protein functions as a GEF for the RhoA and RhoC small GTPases. SmgGDS has various regulatory roles, including small GTPase trafficking and localization and as a molecular chaperone, and interacts with many small GTPases possessing polybasic regions. Two SmgGDS splice variants, SmgGDS ...[more]