Ontology highlight
ABSTRACT:
SUBMITTER: Senecal A
PROVIDER: S-EPMC5555219 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Senecal Adrien A Munsky Brian B Proux Florence F Ly Nathalie N Braye Floriane E FE Zimmer Christophe C Mueller Florian F Darzacq Xavier X
Cell reports 20140626 1
Transcription is a stochastic process occurring mostly in episodic bursts. Although the local chromatin environment is known to influence the bursting behavior on long timescales, the impact of transcription factors (TFs)--especially in rapidly inducible systems--is largely unknown. Using fluorescence in situ hybridization and computational models, we quantified the transcriptional activity of the proto-oncogene c-Fos with single mRNA accuracy at individual endogenous alleles. We showed that, du ...[more]