Ontology highlight
ABSTRACT:
SUBMITTER: Roy-Bellavance C
PROVIDER: S-EPMC5555478 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Roy-Bellavance Catherine C Grants Jennifer M JM Miard Stéphanie S Lee Kayoung K Rondeau Évelyne É Guillemette Chantal C Simard Martin J MJ Taubert Stefan S Picard Frédéric F
G3 (Bethesda, Md.) 20170807 8
Despite many advances, the molecular links between energy metabolism and longevity are not well understood. Here, we have used the nematode model <i>Caenorhabditis elegans</i> to study the role of the yet-uncharacterized gene R148.3 in fat accumulation and lifespan. In wild-type worms, a R148.3<i>p</i>::GFP reporter showed enhanced expression throughout life in the pharynx, in neurons, and in muscles. Functionally, a protein fusing a predicted 22 amino acid N-terminal signal sequence (SS) of R14 ...[more]