Ontology highlight
ABSTRACT:
SUBMITTER: Namba S
PROVIDER: S-EPMC5555573 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Namba Shinichi S Nakano Rei R Kitanaka Taku T Kitanaka Nanako N Nakayama Tomohiro T Sugiya Hiroshi H
PloS one 20170814 8
Tumor necrosis factor α (TNF-α) induces the expression and secretion of interleukin 8 (IL-8), which contributes to synovitis in rheumatoid arthritis (RA). To elucidate the mechanism of the onset of RA, we used synovial fibroblasts without autoimmune inflammatory diseases and investigated MAPK signaling pathways in TNF-α-induced IL-8 expression. Synovial fibroblasts isolated from healthy dogs were characterized by flow cytometry, which were positive for the fibroblast markers CD29, CD44, and CD90 ...[more]