Ontology highlight
ABSTRACT:
SUBMITTER: Sheng XJ
PROVIDER: S-EPMC5555616 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Sheng Xiang-Jun XJ Tu Hunag-Ju HJ Chien Wei-Lin WL Kang Kai-Hsiang KH Lu Dai-Hua DH Liou Horng-Huei HH Lee Ming-Jen MJ Fu Wen-Mei WM
PloS one 20170814 8
PTEN-induced putative kinase 1 (PINK1) is an integral protein in the mitochondrial membrane and maintains mitochondrial fidelity. Pathogenic mutations in PINK1 have been identified as a cause of early-onset autosomal recessive familial Parkinson's disease (PD). The ubiquitin proteasome pathway is associated with neurodegenerative diseases. In this study, we investigated whether mutations of PINK1 affects the cellular stress response following proteasome inhibition. Administration of MG132, a pep ...[more]