Ontology highlight
ABSTRACT:
SUBMITTER: Nikolic MZ
PROVIDER: S-EPMC5555721 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Nikolić Marko Z MZ Caritg Oriol O Jeng Quitz Q Johnson Jo-Anne JA Sun Dawei D Howell Kate J KJ Brady Jane L JL Laresgoiti Usua U Allen George G Butler Richard R Zilbauer Matthias M Giangreco Adam A Rawlins Emma L EL
eLife 20170630
The embryonic mouse lung is a widely used substitute for human lung development. For example, attempts to differentiate human pluripotent stem cells to lung epithelium rely on passing through progenitor states that have only been described in mouse. The tip epithelium of the branching mouse lung is a multipotent progenitor pool that self-renews and produces differentiating descendants. We hypothesized that the human distal tip epithelium is an analogous progenitor population and tested this by e ...[more]