Ontology highlight
ABSTRACT:
SUBMITTER: Hutchison MA
PROVIDER: S-EPMC5555825 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Hutchison M A MA Gu X X Adrover M F MF Lee M R MR Hnasko T S TS Alvarez V A VA Lu W W
Molecular psychiatry 20170214 5
Midbrain dopamine neurons are crucial for many behavioral and cognitive functions. As the major excitatory input, glutamatergic afferents are important for control of the activity and plasticity of dopamine neurons. However, the role of glutamatergic input as a whole onto dopamine neurons remains unclear. Here we developed a mouse line in which glutamatergic inputs onto dopamine neurons are specifically impaired, and utilized this genetic model to directly test the role of glutamatergic inputs i ...[more]