Ontology highlight
ABSTRACT:
SUBMITTER: Goguet M
PROVIDER: S-EPMC5556033 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Goguet Matthieu M Narwani Tarun Jairaj TJ Petermann Rachel R Jallu Vincent V de Brevern Alexandre G AG
Scientific reports 20170814 1
Integrin α<sub>IIb</sub>β<sub>3</sub> mediates platelet aggregation and thrombus formation. In a rare hereditary bleeding disorder, Glanzmann thrombasthenia (GT), α<sub>IIb</sub>β<sub>3</sub> expression / function are impaired. The impact of deleterious missense mutations on the complex structure remains unclear. Long independent molecular dynamics (MD) simulations were performed for 7 GT variants and reference structure of the Calf-1 domain of α<sub>IIb</sub>. Simulations were analysed using a ...[more]