Ontology highlight
ABSTRACT:
SUBMITTER: Reid SE
PROVIDER: S-EPMC5556271 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Reid Steven E SE Kay Emily J EJ Neilson Lisa J LJ Henze Anne-Theres AT Serneels Jens J McGhee Ewan J EJ Dhayade Sandeep S Nixon Colin C Mackey John Bg JB Santi Alice A Swaminathan Karthic K Athineos Dimitris D Papalazarou Vasileios V Patella Francesca F Román-Fernández Álvaro Á ElMaghloob Yasmin Y Hernandez-Fernaud Juan Ramon JR Adams Ralf H RH Ismail Shehab S Bryant David M DM Salmeron-Sanchez Manuel M Machesky Laura M LM Carlin Leo M LM Blyth Karen K Mazzone Massimiliano M Zanivan Sara S
The EMBO journal 20170710 16
Tumor progression alters the composition and physical properties of the extracellular matrix. Particularly, increased matrix stiffness has profound effects on tumor growth and metastasis. While endothelial cells are key players in cancer progression, the influence of tumor stiffness on the endothelium and the impact on metastasis is unknown. Through quantitative mass spectrometry, we find that the matricellular protein CCN1/CYR61 is highly regulated by stiffness in endothelial cells. We show tha ...[more]