Ontology highlight
ABSTRACT:
SUBMITTER: Wu Q
PROVIDER: S-EPMC5556331 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Wu Qian Q Shen Yuanyuan Y Tao Yunlong Y Wei Jiayu J Wang Hao H An Peng P Zhang Zhuzhen Z Gao Hong H Zhou Tianhua T Wang Fudi F Min Junxia J
Cell discovery 20170815
Hereditary hemochromatosis and iron imbalance are associated with susceptibility to bacterial infection; however, the underlying mechanisms are poorly understood. Here, we performed <i>in vivo</i> bacterial infection screening using several mouse models of hemochromatosis, including <i>Hfe</i> (<i>Hfe</i><sup><i>-/-</i></sup> ), <i>hemojuvelin</i> (<i>Hjv</i><sup><i>-/-</i></sup> ), and macrophage-specific <i>ferroportin-1</i> (<i>Fpn1</i><sup><i>fl/fl</i></sup> ;<i>LysM-Cre</i><sup><i>+</i></su ...[more]