RNA-binding proteins in immune regulation: a focus on CCCH zinc finger proteins.
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ABSTRACT:
SUBMITTER: Fu M
PROVIDER: S-EPMC5556700 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Publications
RNA-binding proteins in immune regulation: a focus on CCCH zinc finger proteins.
Fu Mingui M Blackshear Perry J PJ
Nature reviews. Immunology 20161219 2
Nearly 60 CCCH zinc finger proteins have been identified in humans and mice. These proteins are involved in the regulation of multiple steps of RNA metabolism, including mRNA splicing, polyadenylation, transportation, translation and decay. Several CCCH zinc finger proteins, such as tristetraprolin (TTP), roquin 1 and MCPIP1 (also known as regnase 1), are crucial for many aspects of immune regulation by targeting mRNAs for degradation and modulation of signalling pathways. In this Review, we foc ...[more]
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