Complement C5a is present in CSF of human newborns and is elevated in association with preterm birth.
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ABSTRACT:
SUBMITTER: Pataky R
PROVIDER: S-EPMC5556752 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
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Complement C5a is present in CSF of human newborns and is elevated in association with preterm birth.
Pataky Rozalia R Howie Forbes A FA Girardi Guillermina G Boardman James P JP
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20161121 20
Neuroinflammation contributes to developmental brain injury associated with preterm birth, but the mediators that drive it are incompletely understood. Previous studies have shown that complement C5a is present and injurious in the brains of foetal mice exposed to preterm labour. Here, we demonstrate that C5a is present in the cerebrospinal fluid of newborn human infants and that levels are elevated in those born preterm. The difference is not explained by systemic infection. Complement activati ...[more]
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