Ontology highlight
ABSTRACT:
SUBMITTER: Hernandes MS
PROVIDER: S-EPMC5556945 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Hernandes Marina S MS Lassègue Bernard B Griendling Kathy K KK
Journal of cardiovascular pharmacology 20170601 6
Polymerase δ-interacting protein 2 (Poldip2) is a multifunctional protein originally described as a binding partner of the p50 subunit of DNA polymerase δ and proliferating cell nuclear antigen. In addition to its role in DNA replication and damage repair, Poldip2 has been implicated in mitochondrial function, extracellular matrix regulation, cell cycle progression, focal adhesion turnover, and cell migration. However, Poldip2 functions are incompletely understood. In this review, we discuss rec ...[more]