Ontology highlight
ABSTRACT:
SUBMITTER: Kolodziejska KE
PROVIDER: S-EPMC555713 | biostudies-literature | 2005 Mar
REPOSITORIES: biostudies-literature
Kolodziejska Katarzyna E KE Burns Alan R AR Moore Robert H RH Stenoien David L DL Eissa N Tony NT
Proceedings of the National Academy of Sciences of the United States of America 20050321 13
Misfolding and aggregation of proteins play an important part in the pathogenesis of several genetic and degenerative diseases. Recent evidence suggests that cells have evolved a pathway that involves sequestration of aggregated proteins into specialized "holding stations" called aggresomes. Here we show that cells regulate inducible NO synthase (iNOS), an important host defense protein, through aggresome formation. iNOS aggresome formation depends on a functional dynein motor and the integrity ...[more]