Ontology highlight
ABSTRACT:
SUBMITTER: Fahey JR
PROVIDER: S-EPMC5557205 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Fahey James R JR Lyons Bonnie L BL Olekszak Haiyan L HL Mourino Anthony J AJ Ratiu Jeremy J JJ Racine Jeremy J JJ Chapman Harold D HD Serreze David V DV Baker Dina L DL Hendrix N Ken NK
Comparative medicine 20170801 4
Segmented filamentous bacterium (SFB) a gram-positive, anaerobic, and intestinal commensal organism directly influences the development of Th17 helper cells in the small intestine of mice. In NOD mice, SFB colonization interferes with the development of type 1 diabetes (T1D), a T-cell-mediated autoimmune disease, suggesting that SFB may influence Th17 cells to inhibit Th1 populations associated with the anti-β-cell immune response. This effect is a serious concern for investigators who use NOD m ...[more]