Ontology highlight
ABSTRACT:
SUBMITTER: Andreev IA
PROVIDER: S-EPMC5557381 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
European journal of medicinal chemistry 20150410
Although all-oral direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV) treatment is now a reality, today's HCV drugs are expensive, and more affordable drugs are still urgently needed. In this work, we report the identification of the 2-phenyl-4,5,6,7-Tetrahydro-1H-indole chemical scaffold that inhibits cellular replication of HCV genotype 1b and 2a subgenomic replicons. The anti-HCV genotype 1b and 2a profiling and effects on cell viability of a selected representative set of deriv ...[more]