Ontology highlight
ABSTRACT:
SUBMITTER: Marincevic-Zuniga Y
PROVIDER: S-EPMC5557398 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Marincevic-Zuniga Yanara Y Dahlberg Johan J Nilsson Sara S Raine Amanda A Nystedt Sara S Lindqvist Carl Mårten CM Berglund Eva C EC Abrahamsson Jonas J Cavelier Lucia L Forestier Erik E Heyman Mats M Lönnerholm Gudmar G Nordlund Jessica J Syvänen Ann-Christine AC
Journal of hematology & oncology 20170814 1
<h4>Background</h4>Structural chromosomal rearrangements that lead to expressed fusion genes are a hallmark of acute lymphoblastic leukemia (ALL). In this study, we performed transcriptome sequencing of 134 primary ALL patient samples to comprehensively detect fusion transcripts.<h4>Methods</h4>We combined fusion gene detection with genome-wide DNA methylation analysis, gene expression profiling, and targeted sequencing to determine molecular signatures of emerging ALL subtypes.<h4>Results</h4>W ...[more]