Ontology highlight
ABSTRACT:
SUBMITTER: Presley CC
PROVIDER: S-EPMC5557408 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry 20170613 15
Antiplasmodial bioassay guided fractionation of a Madagascar collection of Crinum firmifolium led to the isolation of seven compounds. Five of the seven compounds were determined to be 2-alkylquinolin-4(1H)-ones with varying side chains. Compounds 1 and 4 were determined to be known compounds with reported antiplasmodial activities, while 5 was believed to be a new branched 2-alkylquinolin-4(1H)-one, however, it was isolated in limited quantities and in admixture and therefore was synthesized to ...[more]