Ontology highlight
ABSTRACT:
SUBMITTER: Pazos MA
PROVIDER: S-EPMC5557605 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Pazos Michael A MA Lanter Bernard B BB Yonker Lael M LM Eaton Alex D AD Pirzai Waheed W Gronert Karsten K Bonventre Joseph V JV Hurley Bryan P BP
PLoS pathogens 20170803 8
Excessive neutrophil infiltration of the lungs is a common contributor to immune-related pathology in many pulmonary disease states. In response to pathogenic infection, airway epithelial cells produce hepoxilin A3 (HXA3), initiating neutrophil transepithelial migration. Migrated neutrophils amplify this recruitment by producing a secondary gradient of leukotriene B4 (LTB4). We sought to determine whether this two-step eicosanoid chemoattractant mechanism could be exploited by the pathogen Pseud ...[more]