Pharmacogenetic considerations with dichloroacetate dosing.
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ABSTRACT:
SUBMITTER: James MO
PROVIDER: S-EPMC5558523 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Pharmacogenetic considerations with dichloroacetate dosing.
James Margaret O MO Stacpoole Peter W PW
Pharmacogenomics 20160504 7
The investigational drug dichloroacetate (DCA) is a metabolic regulator that has been successfully used to treat acquired and congenital metabolic diseases and, recently, solid tumors. Its clinical use has revealed challenges in selecting appropriate doses. Chronic administration of DCA leads to inhibition of DCA metabolism and potential accumulation to levels that result in side effects. This is because conversion of DCA to glyoxylate is catalyzed by one enzyme, glutathione transferase zeta 1 ( ...[more]
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