A High-Affinity Repebody for Molecular Imaging of EGFR-Expressing Malignant Tumors.
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ABSTRACT:
SUBMITTER: Yun M
PROVIDER: S-EPMC5558557 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
A High-Affinity Repebody for Molecular Imaging of EGFR-Expressing Malignant Tumors.
Yun Misun M Kim Dong-Yeon DY Lee Joong-Jae JJ Kim Hyeon-Sik HS Kim Hyung-Seok HS Pyo Ayoung A Ryu Yiseul Y Kim Tae-Yoon TY Zheng Jin Hai JH Yoo Su Woong SW Hyun Hoon H Oh Gyungseok G Jeong Jaeho J Moon Myeongju M Min Jung-Hyun JH Kwon Seong Young SY Kim Jung Young JY Chung Euiheon E Hong Yeongjin Y Lee Wansik W Kim Hak-Sung HS Min Jung-Joon JJ
Theranostics 20170625 10
The accurate detection of disease-related biomarkers is crucial for the early diagnosis and management of disease in personalized medicine. Here, we present a molecular imaging of human epidermal growth factor receptor (EGFR)-expressing malignant tumors using an EGFR-specific repebody composed of leucine-rich repeat (LRR) modules. The repebody was labeled with either a fluorescent dye or radioisotope, and used for imaging of EGFR-expressing malignant tumors using an optical method and positron e ...[more]
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