A New Network-Based Strategy for Predicting the Potential miRNA-mRNA Interactions in Tumorigenesis.
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ABSTRACT:
SUBMITTER: Xue J
PROVIDER: S-EPMC5558674 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
A New Network-Based Strategy for Predicting the Potential miRNA-mRNA Interactions in Tumorigenesis.
Xue Jiwei J Xie Fanfan F Xu Junmei J Liu Yuan Y Liang Yu Y Wen Zhining Z Li Menglong M
International journal of genomics 20170802
MicroRNA (miRNA) plays an important role in the degradation and inhibition of mRNAs and is a kind of essential drug targets for cancer therapy. To facilitate the clinical cancer research, we proposed a network-based strategy to identify the cancer-related miRNAs and to predict their targeted genes based on the gene expression profiles. The strategy was validated by using the data sets of acute myeloid leukemia (AML), breast invasive carcinoma (BRCA), and kidney renal clear cell carcinoma (KIRC). ...[more]
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