Ontology highlight
ABSTRACT:
SUBMITTER: Xu J
PROVIDER: S-EPMC5559001 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20170724 32
Interleukin-12 (IL-12) is critical for induction of protective immunity against intracellular bacterial infection. However, the mechanisms for efficient induction of IL-12 in innate response remain poorly understood. Here we report that the B type of carbonic anhydrase 6 (<i>Car6-b</i>, which encoded CA-VI B) is essential for host defense against <i>Listeria monocytogenes</i> (LM) infection by epigenetically promoting IL-12 expression independent of its carbonic anhydrase activity. Deficiency of ...[more]