Ontology highlight
ABSTRACT:
SUBMITTER: Hay DL
PROVIDER: S-EPMC5559101 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Hay Debbie L DL Pioszak Augen A AA
Annual review of pharmacology and toxicology 20151023
It is now recognized that G protein-coupled receptors (GPCRs), once considered largely independent functional units, have a far more diverse molecular architecture. Receptor activity-modifying proteins (RAMPs) provide an important example of proteins that interact with GPCRs to modify their function. RAMPs are able to act as pharmacological switches and chaperones, and they can regulate signaling and/or trafficking in a receptor-dependent manner. This review covers recent discoveries in the RAMP ...[more]