Ontology highlight
ABSTRACT:
SUBMITTER: Mohrbacher AM
PROVIDER: S-EPMC5559312 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Mohrbacher Ann M AM Yang Allen S AS Groshen Susan S Kummar Shivaani S Gutierrez Martin E ME Kang Min H MH Tsao-Wei Denice D Reynolds C Patrick CP Newman Edward M EM Maurer Barry J BJ
Clinical cancer research : an official journal of the American Association for Cancer Research 20170418 16
<b>Purpose:</b> A phase I study was conducted to determine the MTD, dose-limiting toxicities (DLT), and pharmacokinetics of fenretinide delivered as an intravenous emulsion in relapsed/refractory hematologic malignancies.<b>Experimental Design:</b> Fenretinide (80-1,810 mg/m<sup>2</sup>/day) was administered by continuous infusion on days 1 to 5, in 21-day cycles, using an accelerated titration design.<b>Results:</b> Twenty-nine patients, treated with a median of three prior regimens (range, 1-7 ...[more]