Unknown

Dataset Information

0

Chromatin Accessibility Landscape of Cutaneous T Cell Lymphoma and Dynamic Response to HDAC Inhibitors.


ABSTRACT: Here, we define the landscape and dynamics of active regulatory DNA in cutaneous T cell lymphoma (CTCL) by ATAC-seq. Analysis of 111 human CTCL and control samples revealed extensive chromatin signatures that distinguished leukemic, host, and normal CD4+ T cells. We identify three dominant patterns of transcription factor (TF) activation that drive leukemia regulomes, as well as TF deactivations that alter host T cells in CTCL patients. Clinical response to histone deacetylase inhibitors (HDACi) is strongly associated with a concurrent gain in chromatin accessibility. HDACi causes distinct chromatin responses in leukemic and host CD4+ T cells, reprogramming host T cells toward normalcy. These results provide a foundational framework to study personal regulomes in human cancer and epigenetic therapy.

SUBMITTER: Qu K 

PROVIDER: S-EPMC5559384 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications


Here, we define the landscape and dynamics of active regulatory DNA in cutaneous T cell lymphoma (CTCL) by ATAC-seq. Analysis of 111 human CTCL and control samples revealed extensive chromatin signatures that distinguished leukemic, host, and normal CD4<sup>+</sup> T cells. We identify three dominant patterns of transcription factor (TF) activation that drive leukemia regulomes, as well as TF deactivations that alter host T cells in CTCL patients. Clinical response to histone deacetylase inhibit  ...[more]

Similar Datasets

2017-04-20 | GSE85853 | GEO
| S-EPMC7370878 | biostudies-literature
| S-EPMC7889151 | biostudies-literature
| S-EPMC4552614 | biostudies-literature
| S-EPMC10174692 | biostudies-literature
| S-EPMC8181391 | biostudies-literature
| S-EPMC6408149 | biostudies-literature
| S-EPMC7494784 | biostudies-literature
| S-EPMC4878831 | biostudies-literature
| S-EPMC7507092 | biostudies-literature