Ontology highlight
ABSTRACT:
SUBMITTER: Wang SS
PROVIDER: S-EPMC5560119 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Wang Shan-Shan SS Feng Lu L Hu Bao-Guang BG Lu Ying-Fei YF Wang Wei-Mao WM Guo Wei W Suen Chun-Wai CW Jiao Bao-Hua BH Pang Jian-Xin JX Fu Wei-Ming WM Zhang Jin-Fang JF
Molecular therapy. Nucleic acids 20170804
Recombinant tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), as a novel cancer therapeutic, is being tested in phase II and III clinical trials; however, TRAIL resistance remains a big obstacle preventing its clinical application. Considering that TRAIL-induced apoptosis through death receptors DR4 and DR5, their activation may be an alternative pathway to suppress TRAIL resistance. In this study, a negative correlation between DR5 expression and TRAIL resistance was observ ...[more]