Ontology highlight
ABSTRACT:
SUBMITTER: Lee JE
PROVIDER: S-EPMC5560489 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Lee Jung-Eun JE Rayyan Morsi M Liao Allison A Edery Isaac I Pletcher Scott D SD
Cell reports 20170701 2
Dietary restriction promotes health and longevity across taxa through mechanisms that are largely unknown. Here, we show that acute yeast restriction significantly improves the ability of adult female Drosophila melanogaster to resist pathogenic bacterial infections through an immune pathway involving downregulation of target of rapamycin (TOR) signaling, which stabilizes the transcription factor Myc by increasing the steady-state level of its phosphorylated forms through decreased activity of p ...[more]