Dissociated and Reconstituted Cartilage Microparticles in Densified Collagen Induce Local hMSC Differentiation.
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ABSTRACT:
SUBMITTER: Novak T
PROVIDER: S-EPMC5560495 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
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Dissociated and Reconstituted Cartilage Microparticles in Densified Collagen Induce Local hMSC Differentiation.
Novak Tyler T Seelbinder Benjamin B Twitchell Celina M CM Voytik-Harbin Sherry L SL Neu Corey P CP
Advanced functional materials 20160701 30
<b>Decellularized cartilage microparticles, and all associated native signals, are delivered to hMSC populations in a dense, type I collagen matrix.</b> Hybrid usage of native tissue signals and the engineering control of collagen matrices show the ability to induce local infiltration and differentiation of hMSCs. Additionally, the solid cartilage microparticles inhibit bulk cell-mediated contraction of the composite. ...[more]
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