How Ligands Illuminate GPCR Molecular Pharmacology.
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ABSTRACT:
SUBMITTER: Wacker D
PROVIDER: S-EPMC5560499 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
How Ligands Illuminate GPCR Molecular Pharmacology.
Wacker Daniel D Stevens Raymond C RC Roth Bryan L BL
Cell 20170701 3
G protein-coupled receptors (GPCRs), which are modulated by a variety of endogenous and synthetic ligands, represent the largest family of druggable targets in the human genome. Recent structural and molecular studies have both transformed and expanded classical concepts of receptor pharmacology and have begun to illuminate the distinct mechanisms by which structurally, chemically, and functionally diverse ligands modulate GPCR function. These molecular insights into ligand engagement and action ...[more]
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