An optimal strategy for epilepsy surgery: Disruption of the rich-club?

ABSTRACT: Surgery is a therapeutic option for people with epilepsy whose seizures are not controlled by anti-epilepsy drugs. In pre-surgical planning, an array of data modalities, often including intra-cranial EEG, is used in an attempt to map regions of the brain thought to be crucial for the generation of seizures. These regions are then resected with the hope that the individual is rendered seizure free as a consequence. However, post-operative seizure freedom is currently sub-optimal, suggesting that the pre-surgical assessment may be improved by taking advantage of a mechanistic understanding of seizure generation in large brain networks. Herein we use mathematical models to uncover the relative contribution of regions of the brain to seizure generation and consequently which brain regions shou

SUBMITTER: Lopes MA 

PROVIDER: S-EPMC5560820 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature