Ontology highlight
ABSTRACT:
SUBMITTER: Jesse S
PROVIDER: S-EPMC5561056 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Jesse Sarah S Bayer Hanna H Alupei Marius C MC Zügel Martina M Mulaw Medhanie M Tuorto Francesca F Malmsheimer Silke S Singh Karmveer K Steinacker Jürgen J Schumann Uwe U Ludolph Albert C AC Scharffetter-Kochanek Karin K Witting Anke A Weydt Patrick P Iben Sebastian S
Scientific reports 20170817 1
PGC-1α is a versatile inducer of mitochondrial biogenesis and responsive to the changing energy demands of the cell. As mitochondrial ATP production requires proteins that derive from translation products of cytosolic ribosomes, we asked whether PGC-1α directly takes part in ribosomal biogenesis. Here, we show that a fraction of cellular PGC-1α localizes to the nucleolus, the site of ribosomal transcription by RNA polymerase I. Upon activation PGC-1α associates with the ribosomal DNA and boosts ...[more]